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Where and why do you think an adaptation occurred that led to the development of sickle cell disease and what is the pathophysiology of the adaptation?

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D​‌‍‍‍‌‍‌‍‍‍‌‌‌‍‌‌‌‌‌‌​iscussion Instructions:
1. Sickle cell disease is an adaptive response against malaria. Discuss and identify the pathogen and transmission of malaria.
2. Where and why do you think an adaptation occurred that led to the development of sickle cell disease and what is the pathophysiology of the adaptation?
3. Why do people who no longer live in parts of t​‌‍‍‍‌‍‌‍‍‍‌‌‌‍‌‌‌‌‌‌​he world where malaria is prevalent still develop sickle cell disease and how and why does it occur?
4. How can we advise families with this debilitating disease?
Two professional peer-reviewed scholarly journal references no older than 5 years
Posting is substantive demonstrating critical thinking and thoughts delving deeper into the discussion topic​‌‍‍‍‌‍‌‍‍‍‌‌‌‍‌‌‌‌‌‌​.

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